RT Journal Article
SR Electronic
T1 Urinary antigen of S. pneumoniae in the microbiological diagnosis of lower respiratory tract infections
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2707
VO 42
IS Suppl 57
A1 Sindy Cedeño de Jesús
A1 José Gutierrez Fernandez
A1 Antonio Sorlózano
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P2707.abstract
AB Background and objective:The rapid immunochromatographic test for detection of Streptococcus pneumoniae antigen in urine has experienced a request increasing to clinical microbiology laboratories. We compared with conventional microbiological isolation methods and evaluated the impact of the application of this test in the etiological diagnosis in lower respiratory tract infections.Patients and method:Six hundred and sixteen determinations were retrospectively studied, whom BinaxNOW® urinary antigen S. pneumoniae was performed. All patients over 14 years old, admitted to the Virgen de las Nieves University Hospital (Granada, Spain) from November 2010, were selected. All patients were divided into two groups: lower respiratory tract infection (LRTI) and no lower respiratory tract infection (No LRTI).Results:The diagnosis of LRTI was based on clinical, radiological and/or analytical criteria (529 cases). Of the 616 antigenurias, only 8.6% were positive. In 7/163 sputum cultures the S. pneumoniae was isolated (5 positive antigenurias), 3/152 blood cultures (3 positive antigenurias), 1/10 BAL. In 39% of cases no additional microbiological tests were carried out. On the other hand, 22.5% of 662 samples had a microbiological etiology. The contribution of the antigenuria at the etiologic diagnosis was a 6%, being more frequently positive in pneumonia (39/288). In COPD patients, only three cases had evidence of active pneumococcal infection through antigenuria.Conclusions:This technique should be carefully interpreted, especially those with severe infections, as well as, be used in a complementary manner and not in substitution of other microbiological tests.