@article {VosP2680, author = {Robin Vos and David Ruttens and Stijn Verleden and Elly Vandermeulen and Jana Somers and Dirk Van Raemdonck and Jonas Yserbyt and Lieven Dupont and Bart Vanaudenaerde and Geert Verleden}, title = {Immediate post-operative bronchoalveolar neutrophilia is associated with FEV1 early after lung transplantation}, volume = {42}, number = {Suppl 57}, elocation-id = {P2680}, year = {2013}, publisher = {European Respiratory Society}, abstract = {BackgroundSmall case series have demonstrated that both donor and immediate post-operative recipient bronchoalveolar lavage (BAL) cytokine levels following lung transplantation (LTx) are associated with primary graft dysfunction (PGD) and recipient survival. We investigated whether recipient BAL neutrophilia during the first 48 hours post-transplant is associated with FEV1 early after LTx.MethodsA total of 198 transplant recipients (SS n=190/HL n=8), transplanted between 2002 and 2012, in whom routine BAL was performed during the first 48 hours post-transplant ; were retrospectively assessed for BAL neutrophilia, which was correlated with FEV1 (\%pred) at 1 and 3 months post-operatively.ResultsBAL was performed 18.3({\textpm}10.6) hours after allograft implantation. In univariate analysis, BAL neutrophilia inversely correlated with FEV1 at 3 months after LTx (p=0.025, r{\texttwosuperior}=0.027) and a similar trend was seen with FEV1 after 1 month (p= 0.067, r{\texttwosuperior}=0.021). In multivariate regression analysis, adjusted for duration of donor ventilation, donor pO2 at prelevation, allograft ischemic time, ECMO-use and PGD-score in the first 72 hours, BAL neutrophilia was still statistically significantly associated with FEV1 at 3 months (p=0.031).ConclusionsImmediate post-operative BAL neutrophilia is associated with FEV1 early after LTx, which may allow for early intervention to further improve outcome.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/P2680}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/P2680.full.pdf}, journal = {European Respiratory Journal} }