TY - JOUR T1 - The dynamics of oxidative stress markers in patients with bronchial asthma (BA) during the course of liposome nanoparticle admission (a randomized placebo-controlled study) JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P4117 AU - Alexander Lisitsa AU - Igor Klimanov AU - Svetlana Soodaeva AU - Alexander Averyanov Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P4117.abstract N2 - Background: It’s well-known that a number of cells are damaged due to oxidative stress in inflammation processes. The aim of the study was to investigate the dynamics of oxidative stress markers in BA patients during the 24-week course of treatment by the liposome nanoparticle inhalation (LI).Materials and methods: The prospective, single-blind, randomized, placebo controlled, parallel-group study was performed. 58 patients (age 67.5±12.3; male 68.3%) with partly controlled and uncontrolled BA were enrolled (FEV1>50%). Group1 contains 30 patients who received a LI by compressor nebulizer once a day in addition to traditional therapy; group2 - 28 patients who received a traditional therapy only (control).Antioxidant activity was determined by the estimation of the total nitrite/nitrate (TNN) level in exhaled breath condensate (EBC) and in blood plasma before and after the investigation period (measured by Griess method).Results: It was shown the statistically significant decrease of the TNN level both in EBC and blood plasma in group1 compared with control (59.7±38.7 vs 20.1 ±9.2 µmol/l, p=0.01; 56.4.7±37.5 vs 31.6 ±15.3 µmol/l, p<0.03 respectively). The BPAA level statistically significant increased from 1.89±0.8 to 3.57±0.7 units in group 1 while in control group this factor was at the same border (2.1±0.4).Conclusion. It was shown the effectiveness of the inhalation of nanoliposome preparation in complex therapy of the BA patients; that was confirmed by statistical significantly decreasing of the inflammation markers levels compared to placebo. ER -