TY - JOUR T1 - The clinical impact of long-acting bronchodilators in newly diagnosed COPD patients JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P699 AU - Sei Won Lee AU - Jinhee Kim AU - Yeon-Mok Oh AU - Sang-Do Lee Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P699.abstract N2 - Background: Although the efficacy of long-acting bronchodilators has been well documented in randomised controlled studies, whether similar effects are obtained in real-life clinical practice is not clear. In this study, we analysed the effect of long-acting bronchodilators in newly-diagnosed COPD patients.Methods: The Korean Health Insurance databases were used. Participants ≥ 40-years-old who had not been diagnosed with COPD between 2007 and 2008 but were diagnosed and prescribed COPD medication in 2009 were designated as newly-diagnosed COPD patients. Patients were divided into three groups based on the use of bronchodilators, a long-acting bronchodilator (LA-B), a short-acting bronchodilator (SA-B) and an oral medication (OM) group.Results: A total of 77,480 newly-diagnosed COPD patients with a mean age of 68.5 years, among which 43,530 (56.2%) were men, were included in the study. ER visits and hospitalisation were associated with SA-B group, male gender, older age, Medicaid coverage, tertiary healthcare centre visits and higher comorbidities. Multivariate analysis showed that the SA-B group was associated with more ER visits, recurrent ER visits, hospitalisation and recurrent hospitalisation (adjusted ORs [95% confidence intervals] =4.32 [3.93–4.75], 6.19 [5.24–7.30], 5.04 [2.95–3.39], and 8.49 [7.67–9.39], respectively) compared with the LA-B group. Medical utilisation cost was also higher in the SA-B group.Conclusion: Long-acting bronchodilator use was associated with lower rates of hospitalisation, fewer ER visits and lower medical costs in newly-diagnosed COPD patients in real-life clinical practice. ER -