RT Journal Article
SR Electronic
T1 Cardiopulmonary exercise testing in patients with common variable immunodeficiency and agammaglobulinemia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4195
VO 42
IS Suppl 57
A1 Maria Carrabba
A1 Maria Cristina Pietrogrande
A1 Aberto Pierini
A1 Sergio Caravita
A1 Marianna Giuditta
A1 Rosa Maria Dellepiane
A1 Giovanna Fabio
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P4195.abstract
AB Cardiopulmonary exercise testing (CPET) is considered the gold standard to study a patient's exercise intolerance and its causes. An heterogeneous group of chronic lung diseases occurs in CVID and X-LA and can affect the prognosis. The lung disease is usually assessed by spirometry, lung CT-scan, and 6-minute walking test (6-MWT). Aims: To characterize the pulmonary function and exercise capacity of adult patients with CVID and X-LA. Methods: CPET was performed by six CVID and two X-LA patients. Spirometry, CT-lung scan and 6-MWT data were acquired. Results: All the patients reached a maximal effort. Five patients had abnormalities in the aerobic exercise capacity at peak (VO2 peak) and the efficiency of ventilatory response to exercise at the anaerobic thresholds. On the contrary, 6-MWT was almost normal in seven patients. Conclusions: CPET can improve early detection of ventilatory disfunctions and help to set a highly individualized training intensity for exercise prescription to improve prognosis and quality of life.