PT  - JOURNAL ARTICLE
AU  - Maria Carrabba
AU  - Maria Cristina Pietrogrande
AU  - Aberto Pierini
AU  - Sergio Caravita
AU  - Marianna Giuditta
AU  - Rosa Maria Dellepiane
AU  - Giovanna Fabio
TI  - Cardiopulmonary exercise testing in patients with common variable immunodeficiency and agammaglobulinemia
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P4195
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P4195.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P4195.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Cardiopulmonary exercise testing (CPET) is considered the gold standard to study a patient's exercise intolerance and its causes. An heterogeneous group of chronic lung diseases occurs in CVID and X-LA and can affect the prognosis. The lung disease is usually assessed by spirometry, lung CT-scan, and 6-minute walking test (6-MWT). Aims: To characterize the pulmonary function and exercise capacity of adult patients with CVID and X-LA. Methods: CPET was performed by six CVID and two X-LA patients. Spirometry, CT-lung scan and 6-MWT data were acquired. Results: All the patients reached a maximal effort. Five patients had abnormalities in the aerobic exercise capacity at peak (VO2 peak) and the efficiency of ventilatory response to exercise at the anaerobic thresholds. On the contrary, 6-MWT was almost normal in seven patients. Conclusions: CPET can improve early detection of ventilatory disfunctions and help to set a highly individualized training intensity for exercise prescription to improve prognosis and quality of life.