RT Journal Article
SR Electronic
T1 Predicting pulmonary hypertension with standard computed tomography angiography
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4091
VO 42
IS Suppl 57
A1 Onno Spruijt
A1 Frances de Man
A1 Rutger Lelij
A1 Harm Jan Bogaard
A1 Nico Westerhof
A1 Anton Vonk-Noordegraaf
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P4091.abstract
AB Rationale: Since standard non-ECG gated computed tomography angiography (CTA) is a widely available and frequently used diagnostic test and is part of the normal clinical work-up of pulmonary hypertension (PH), predicting PH by CTA could be of clinical interest. Although research has shown the value of measurements of the pulmonary artery (PA) for predicting PH, less is known about the predictive value of ventricular measurements on CTA.Objective: To investigate whether the predictive value of CTA for PH can be increased when PA and ventricular measurements are combined.Methods: Retrospective study design. 59 PH patients (48 patients with pulmonary arterial hypertension and 11 patients with chronic trombo-embolic pulmonary hypertension) and 28 non-PH controls underwent right heart catheterization and CTA. Pulmonary artery/ascending aorta diameter ratio on the axial view (PA/AAAX), right ventricle/left ventricle diameter ratio on the axial view (RV/LVAX) and RV/LV diameter ratio on a manually reconstructed four chamber view (RV/LV4CH) were obtained as CT parameters for predicting PH.Results: Multivariate binary logistic regression analysis showed that only PA/AAAX and RV/LV4CH, were independent predictors of PH. The highest sensitivity in combination with the highest positive predictive value (PPV) was obtained when PA/AAAX and RV/LV4CH were combined (Table 1).View this table:Conclusion: Predicting PH using the combination of the PA/AAAX and RV/LV4CH is better than using PA/AAAX alone.