TY - JOUR T1 - Gender differences in hospitalized patients with acute exacerbation of COPD JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2165 AU - Esra Uzaslan AU - Ezgi Cetindogan AU - Asli Gorek Dilektasli AU - Funda Coskun AU - Dane Ediger AU - Ercument Ege Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2165.abstract N2 - Introduction: The prevalence and hospitalization of COPD in women are increasing in developing countries.Little is known about gender differences in acute exacerbations of COPD (AECOPD).Objective: We aimed to evaluate if gender is a risk factor that has effects on clinical characteristics of the patients with AECOPD. Methods: We included patients whom admitted and hospitalized a tertiary reference center with AECOPD between 2011-2013 years.Medical records of the study participants have been screened retrospectively for 24 months. Results :A total of 242 patients (209 males, and 33 females) hospitalized for AECOPD were included. Mean age, clinical findings and routine laboratory tests on admission did not differ between males and females.In arterial blood gas analyzes PaCO2 levels were found to be significantly higher in females than the males [53.8 mmHg (min:28.6-max:102.5) mmHg],[42.4 mmHg (min:24 - max:109.1 mmHg].Also HCO3 and pH levels of females were significantly higher than males. Percentage of the patient more than one comorbidities were significantly higher in females than the males (30% vs 11%).Diabetes mellitus (F/M: 27%/12%, p<0.05), hypertension (F/M: 36% /21%, p=0.07), and obesity (F/M: 21%/1%,p<0.05) were also more prevelant in females with AECOPD. Lung cancer was only detected in males(10%). Gender was not an effecting factor on mortality in patients with AECOPD. Conclusion:Female COPD patients were tend to be more hypercapnic than the males on admission.Although comorbidities are common in hospitalized patients, their relative distribution varies by gender. Therefore the effects of different comorbidities in gender related AECOPD hospitalization needs to be verified with further studies. ER -