PT - JOURNAL ARTICLE AU - Monique Oswald-Mammosser AU - Marie Fleury AU - Irina Enache AU - Cristina Pistea AU - Christine Tranchant AU - Anne Charloux TI - Prognostic value of iterative lung function testing in amyotrophic lateral sclerosis (ALS) DP - 2013 Sep 01 TA - European Respiratory Journal PG - P1928 VI - 42 IP - Suppl 57 4099 - http://erj.ersjournals.com/content/42/Suppl_57/P1928.short 4100 - http://erj.ersjournals.com/content/42/Suppl_57/P1928.full SO - Eur Respir J2013 Sep 01; 42 AB - We hypothesized that, in addition to baseline values, changes in lung function values measured during the 6 first mo of follow-up may be prognostic in ALS.Methods113 patients from the Strasbourg ALS Centre completed follow-up of slow vital capacity (VC), maximal inspiratory pressure (MIP) and sniff nasal pressure (SNIP) till death. The best of either MIP or SNIP (called S/MIP) was used. Parameters were measured every 3 mo.ResultsPatients’ characteristics are presented in Table 1.View this table:patients charateristics at baselineMean survival was 20 (+/-19) months.Baseline values were related to survival. A VC <80% had a positive predictive value (PPV) of survival <12 mo of 74%, and <18 mo, of 86%. S/MIP <60cmH2O had a PPV of survival <18 mo of 81%. S/MIP >60 cmH2O was associated with survival >6 mo in 97% of patients.Considering changes in VC, a decrease >40% at 3 mo had a PPV of survival <6 mo of 83%, and a decrease >40% at 6 mo had a PPV of survival <12 mo of 100%. Considering S/MIP, a decrease <40 % of initial value at 3 mo was associated with survival >6 mo in 91% of patients, and >12 mo in 80% of patients.ConclusionsThis first study of changes in VC and S/MIP at 3 and 6 mo of follow-up show they are highly predictive of death in ALS.