TY - JOUR T1 - A study of antibiogram assay, risk factors and etiology of ventilator associated pneumonia (VAP) in a tertiary care hospital of Pakistan JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2745 AU - Tayyaba Ijaz AU - Sana Aslam AU - Sarwat Raja AU - Bilal Ahmad AU - Aftab Anjum AU - Saadia Ijaz Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2745.abstract N2 - Background: Ventilator associated pneumonia (VAP) is a kind of nosocomial infection among the patients upon mechanical ventilation; resulting in high mortality rate among individuals admitted in Intensive Care Units (ICU).Objective: The objective of this study was to determine the etiology, trends of antibiotic resistance and other risk factors contributing towards the severity of VAP in an ICU of a tertiary care hospital in Pakistan.Methods: For the purpose, a total of 250 suspected cases of VAP were selected during 2010-2012 after following Clinical Pulmonary Infectious Score Chart. The samples of tracheal aspirates processed for evidence of microbes. Antibiogram assay was conducted using variety of commercially available antibiotics. Other parameters/risk factors contributed towards high mortality/deterioration were also observed.Results: A total of 167(66.8%) VAP patients admitted in ICU were identified. in the study. The isolates were Staphylococci, Streptococci, Acinetobacter, Pseudomonas, Klebsiella, Escherichia, fungi etc.Most of the isolates found resistant (>40%) to Augmentin, Gentamycin, Cefazolin, Ceftriaxone, Ceftazidime, Doxycycline, Tetracycline, Clindamycin and Ciprofloxacin. Maximum antimicrobial activity was observed for Meropenem, Tobramycin, Amikacin, Fucidin, Linezolid, Vancomycin andTazocin.Tygecycline being superior to others. High mortality (69.5%) was observed in VAP cases. Major factors contributed towards mortality were the length of ventilation, age, treatment failure, organ deterioration and underlying illness.Conclusions:This study indicate poor infection control and emergence of resistant microbes. ER -