TY - JOUR T1 - Incidence of lung cancer in smokers with and without COPD: Observational study JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P4509 AU - Virginia Moya AU - Ana Boldova AU - Elena Forcen AU - Elisa Minchole AU - Jose María Marín Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P4509.abstract N2 - Population-based studies suggest that COPD increases the risk of lung cancer(LC) among smokers.The aim is to evaluate the influence of COPD in smokers compared to smokers,without comorbidities (Charlson index = 0) in the incidence of LC. Methods: This is an observational prospective cohort study of 596 smokers, 298 without and 298 with COPD(GOLD criteria).We included all patients that all smoke > 15 pack / year without comorbidities (Charlson index = 0) except for COPD.Results: 298 subjects with COPD were smokers and 298 were smokers without COPD. Regarding smoking 42.3% were current smokers at the time of diagnosis and 57.7% were former smokers. Among non-COPD smokers, 4 patients died of a lung cancer(1.3%).Among 33 smokers COPD had a lung cancer(11.1%). Both data were compared by the χ 2 test (p <0.001).When calculating the survival curves depending on the severity of COPD and LC incidence, It shows that a lower severity of illness is also associated with an increased risk of lung cancerConclusions: COPD increases the risk of developing LC among smokers, regardless of other risk factors A lower severity of illness is also associated with an increased risk of LC. ER -