PT - JOURNAL ARTICLE AU - Anne Olland AU - Sandrine Hirschi AU - Jérémie Reeb AU - Stéphane Renaud AU - Nicola Santelmo AU - Anne Roche AU - Pierre-Emmanuel Falcoz AU - Romain Kessler AU - Gilbert Massard TI - Negative consequences of immunosuppressive therapy on bronchial healing following lung transplantation (LTx) DP - 2013 Sep 01 TA - European Respiratory Journal PG - P2676 VI - 42 IP - Suppl 57 4099 - http://erj.ersjournals.com/content/42/Suppl_57/P2676.short 4100 - http://erj.ersjournals.com/content/42/Suppl_57/P2676.full SO - Eur Respir J2013 Sep 01; 42 AB - IntroductionImmunosuppressive therapy presents with well-known anti-proliferative properties. We studied the impact of different immunosuppressive combinations on bronchial healing in LTx.MethodWe conducted a retrospective historical study on all LTx performed in a single center between January 2004 and May 2012. We recorded the demographic characteristics of the recipients and the donors. We focused on lung disease in the recipient, denutrition, surgical technique for transplantation, graft ischemia, primary graft dysfunction, mechanical ventilation support, lung infection, and the post-operative combination of immunosuppressive therapy. These characteristics were compared to bronchial complications defined as: (i) symptomatic dehiscence (extended chest tube drainage, need for surgery, recipient death) or (ii) symptomatic stenosis (bronchoscopic dilation or stenting).ResultsAmong 169 LTx, we found 35 bronchial complications leading to death in 7 patients. Meanwhile 134 patients remained unharmed. Both groups received overall the same amount of steroids. Patients with the combination basiliximab/steroid/tacrolimus/mycophenolate had significantly more bronchial complications (p=0.03) in comparison to patients with the combination steroid/ ciclosporin/azathioprine. There was no significant difference for the other studied factors.ConclusionThe combination basiliximab/steroid/tacrolimus/mycophenolate has a negative effect on bronchial healing. The anti-proliferative effects of immunosuppressive drugs should be studied when given in a combination and not as a single drug.