RT Journal Article SR Electronic T1 Procalcitonin (PCT) and C-reactive protein (CRP) as markers of the differential diagnosis of severe community acquired pneumonia (sCAP) JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P2714 VO 42 IS Suppl 57 A1 Oleksii Bielosludtsev A1 Kseniia Bielosludtseva A1 Olexander Nazarenko YR 2013 UL http://erj.ersjournals.com/content/42/Suppl_57/P2714.abstract AB Aim: to optimizate the tactics to sCAP depending on the etiological factors including levels of PCT and CRP.Methods. From 27 patients (pts) who were admitted to the intensive care with sCAP (age - 57,85±2,58) diagnosis was confirmed at 24 pts (the main group). Methods included clinical, laboratory, instrumental, microbiological, bacteriological.Results. According to etiological factor study group was divided into 2 subgroups: 1 - 19 pts with bacterial sCAP, 2 - 5 HIV-positive pts with sCAP, 4 of them had Pneumocystis sCAP, 1 - pneumococcal. In subgroup 1 of pts with bacterial etiology level of PCT and CRP were respectively 12,85±2,91 ng/ml (normal - up to 0,1 ng / ml) and 204,49±20,47 mg / l (normal - up to 10 mg/l). In HIV-infected patients with Pneumocystis jirovecii PCT level was slightly above normal and was 0,35±0,12 ng/ml, and CRP level was normal (8,9 mg/l). 3 patients were excluded from the study with severe heart failure, acute myocardial infarction and pulmonary neoplasm. There level of PCT was within normal limits (0,079±0,033 mg/ml), and CRP level was 34,38 mg/l.Conclusions: PCT and CRP can be used as markers of etiologic of severe CAP: 1) at increasing of PCT up to 10-15 ng/ml and CRP up to 180-220 mg / it should be regarded as bacterial sCAP and continue antibiotic therapy;2) at slight increasing of PCT (up to 0,2-0,4 ng / ml) and normal CRP it is value to exclude immunodeficiency state and optionally assign a specific therapy including antipneumocystic;3) at normal levels of PCT regardless of CRP diagnostic search should be continue to exclude other pathology, which could mimic the sCAP.