RT Journal Article
SR Electronic
T1 Comparison of lung ventilation volume measurements made with single and separate breath-hold hyperpolarized 3-helium and proton MRI
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3431
VO 42
IS Suppl 57
A1 Samuel Janoff
A1 Helen Marshall
A1 General Leung
A1 Juan Parra-Robles
A1 Xiaojun Xu
A1 Salman Siddiqui
A1 Chris Brightling
A1 Jim Wild
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P3431.abstract
AB OverviewHyperpolarized (HP) gas MRI can be combined with spatially registered proton (1H) images of the lung to calculate percentage lung ventilation (PV). However, any lung inflation difference between separate 1H and 3He breath-holds results in errors.AimTo increase PV accuracy using a novel single breath-hold 3He and 1H acquisition.Methods10 asthma patients were scanned with 3He MRI. The protocol was repeated at baseline to assess short-term reproducibility. Patients inhaled 1L (35% 3He/65% N2) from FRC. Immediately following this (in the same breath-hold) 1H MRI was acquired. A separate breath-hold set of 1H images were also acquired at FRC+1L.Ventilated volume (vV), lung volume (LV) and PV(vV/LV) were calculated. PVSingle used 3He and 1H images from the same breath hold. PVSeparate used 1H images from the separate breath hold.ResultsFigure 1 shows how lung inflation variation between separate breath-hold 3He (a) and 1H (b) MRI affects PV (c). Acquisition of 3He and 1H MRI during single breath-hold (a,d) gave a more accurate PV measurement (e).Mean baseline difference was 2.19±10.1% for PVSingle and 9.79±22.5% for PVSeparate, a significant difference (p<0.04).ConclusionPercentage lung ventilation measurements using single breath-hold 3He and 1H acquisition were more reproducible than measurements using separate breathold 3He and 1H images.FundingAIRPROM FP7 and Novartis.