PT  - JOURNAL ARTICLE
AU  - Nicole Beydon
AU  - Arnaud Chambellan
AU  - Alberti Corinne
AU  - Muriel Lebourgeois
TI  - Reliability and comparison of different methods to assess nasal nitric oxide during tidal breathing in children
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P1089
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P1089.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P1089.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Background Tidal breathing (VT) technique to measure nasal nitric oxide (nNO) is used to screen children for primary ciliary dyskinesia (PCD), but new portable devices allow measurement over a period of time without any possible control of the breathing patternObjectives 1) to compare different methods of VT nNO measurements, the recommended mean of 5 peaks and 10s of regular breathing, and the mean of last 30s of a 45s tidal breathing period 2) to check inter-nostrils repeatability of VT measuresMethods Multicentre online nNO measurements study (chemiluminiscence, Seres, France, Aerocrine, Sweden) in children with suspected PCD. Measures were recorded using a nasal olive during apnea (AP), expiration against resistance (ExRe), and VT with a 0.3L.min-1 sample flow.Results We studied 139 children (66 girls, median [range] age 9.1 [2.9-17.9] y). Comparisons between techniques are in table. VT measure was impossible to record in one nostril in 18 children. nNO values from 2 nostrils were highly correlated for all techniques (p<0.0001, rhô from 0.93 to 0.99). The 2 nostrils measurements were within 10% of the maximum value in 69% AP, 89% ExRe, 33% 5 peaks, 35% 10s, 32% 30s.View this table:nNO values according to techniques and methodsConclusion VT nNO values obtained using different methods are not interchangeable. Discrepancy between the nostrils is more likely to occur with VT technique, which implies to systematically measure the 2 nostrils with this technique.