TY - JOUR T1 - Prognostic value of dual-time-point <sup>18</sup>F-FDG PET in fibrotic idiopathic interstitial pneumonia JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2320 AU - Yukihiro Umeda AU - Yoshiki Demura AU - Chisato Honjo AU - Yasuyuki Sumida AU - Miwa Morikwa AU - Masaki Anzai AU - Shingo Ameshima AU - Tatsuro Tsuchida AU - Hidehiko Okazawa AU - Takeshi Ishizaki AU - Tamotsu Ishizuka Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2320.abstract N2 - Purpose: The aim of this prospective study was to clarify whether dual-time-point [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG PET) imaging results are useful to predict long-term survival of idiopathic pulmonary fibrosis (IPF) and fibrotic nonspecific interstitial pneumonia (f-NSIP) patients.Methods: Seventy patients with IPF (n=43) or f-NSIP (n=27) underwent 18F-FDG PET examinations at 2 time points; 60 minutes (early imaging) and 180 minutes (delayed imaging) after 18F-FDG injection. Standardized uptake value (SUV) at each point and the retention index value (RI-SUV) calculated from those were evaluated, then the results were compared with survival and serial trends in pulmonary function indices.Results: The early SUV value for lung lesions in patients with f-NSIP (1.31±0.45) was significantly higher than that in those with IPF (1.09±0.31, P=0.014), whereas the delayed SUV and RI-SUV values were not significantly different. There was no significant difference in survival between the patients groups (P=0.24). The 3-year survival of all patients (IPF and f-NSIP) negative for RI-SUV (&lt;0%) was 96.7% as compared to 50.8% for those with positive RI-SUV (≥0%; P&lt;0.0001). Positive RI-SUV was shown to be a robust predictor of survival in both groups (IPF, HR 4.67, 95% CI 1.23-17.8, P=0.023; f-NSIP, HR 8.88, 95% CI 1.04-75.9, P=0.046) when compared with baseline FVC, DLCO, and pathological diagnosis.Conclusion: Our results demonstrate that positive RI-SUV is strongly predictive of long-term survival and changes in pulmonary function in patients with IPF or f-NSIP. ER -