PT  - JOURNAL ARTICLE
AU  - Manuel Barros
AU  - Claudia Cartagena
AU  - Mirtha Reyes
AU  - Maria Jose Perez
TI  - Symptom profile in obese asthmatics compared with non obese asthmatics in stable state
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P2125
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P2125.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P2125.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - It has been proposed that in asthmatic subjects with obesity (O) it is more difficult to achieve symptom control when compared with non obese patients (NO). The aim of this study was to establish a symptom profile in outpatient asthmatics, comparing O with NO subjects.We included patients with confirmed Asthma, who had filled prescriptions for at least 1 year. They should not have other respiratory illness or systemic uncontrolled disease. Subjects answered the Asthma Control Questionnaire (ACT), and clinical charts were reviewed for demographic, medical and therapeutic information. ACT scores from 5 (worst control) to 25 (total control). Obesity was defined as BMI ≥30 Kg/m2. Statistical analysis was done with t test and chi2. Results are presented as mean±SD.223 patients were included (93 O, 130 NO), with FEV1 77±21%, and asthma for 21.5±14.2 years. O group was older (55.6±15.6 vs 48.2±20.8 years old; p=0.004), had more women (85 vs 64%, p=0.001), less atopy (71 vs 84%, p <0.04) and worse symptom control (ACT 13.7±5.2 vs 15,5±5.0; p<0.02). Symptom profile showed in O more activity impairment (2.9±1.3 vs 3.4±1.2; p=0.01), nocturnal dyspnoea (2.4±1.4 vs 3.1±1.5; p<0.002) and use of rescue inhaler (2.1±1.4 vs 2.6±1.3; p<0.02). No differences were found in FEV1, diurnal dyspnoea, self evaluation of control, smoking status, asthma duration, rhinitis or eosinophil count. Controller treatment included Inhaled steroids only (ICS) in 19% of O vs 24% in NO, ICS/LABA combination in 61 vs 69% and > 2 controller drugs in 19 vs 7% (p <0.03).In this group of asthmatic patients we found that O subjects had worse control than NO, with a different symptom profile, despite receiving more treatment.