RT Journal Article SR Electronic T1 Impact of candida spp. colonization of respiratory tract in patients with intensive care unit-acquired pneumonia JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P2077 VO 42 IS Suppl 57 A1 Silvia Terraneo A1 Miquel Ferrer A1 Mariano Esperatti A1 Marta Di Pasquale A1 Valeria Giunta A1 Mariano Rinaudo A1 Hugo Loureiro A1 Rogelio Peralta A1 Francesca De Rosa A1 Gianluigi Li Bassi A1 Stefano Centanni A1 Antoni Torres YR 2013 UL http://erj.ersjournals.com/content/42/Suppl_57/P2077.abstract AB Introduction: In immunocompetent patients with respiratory infections, concomitant colonization by Candida spp. seems not clinically relevant. However, Candida spp. airway colonization could promote development of ICU-acquired pneumonia (ICUAP) due to Pseudomonas aeruginosa and multi-drug resistant bacteria, prolonged stay and worse outcomes. We compared characteristic and outcomes of patients with ICUAP, with or without airway colonization by Candida spp.Methods: We prospectively collected 385 consecutive immunocompetent patients with ICUAP, clustered according to the presence or absence in sputum, tracheal aspirate or bronchoalveolar lavage of Candida spp.Results: Candida spp. was found in 82 (21%) patients. Colonized patients had a higher APACHE-II, SAPS-II and SOFA scores at baseline and higher rate of diabetes and chronic renal failure. Conversely, previous use of antibiotics and steroid therapy was less frequent. The rate of etiologic diagnosis was lower, as well as the isolation of Enterobacteriaceae and Pseudomonas aeruginosa . The length of stay and mortality were similar in both groups. Following adjustment for potential confounders, patients with Candida spp. remained with similar ICU (adjusted odds-ratio (OR) 1.70, 96, 95% confidence interval (CI) 0.81-3.59, p=0.16) and hospital mortality (adj. OR 1.23, 95% CI 0.63-2.42, p=0.54).Conclusion: Patients with ICUAP and Candida spp. colonization had lower rates of Enterobacteriaceae and P. aeruginosa aetiology. Despite worse initial clinical presentation, they had similar outcomes to patients not colonized by Candida spp.Supported: IDIBAPS, CibeRes(CB06/06/0028)-ISCiii, 2009 SGR 911.