PT  - JOURNAL ARTICLE
AU  - V. Iachnyk
AU  - I. Dziublyk
AU  - A. Dziublyk
AU  - G. Kapitan
AU  - O. Mukhin
AU  - L. Chechel
AU  - R. Sukhin
AU  - N. Nedlinska
AU  - V. Kliagin
AU  - O. Obertinska
TI  - Spectrum of viral pathogens in adults patients with infectious exacerbations of bronchial asthma
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P1881
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P1881.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P1881.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Investigation of the spectrum of viral pathogens in patients with infectious exacerbation (IE) of bronchial asthma (BA).Nasal swabs from 116 patients with IE of BA (60 men and 56 women aged 26 - 76 years), confirmed by the results of complex clinical-functional and laboratory methods. Laboratory diagnosis of viral infection was performed using polymerase chain reaction in real time (PCR-FRT). With the PCR-FRT detected antigens of influenza viruses A and B (Influenza virus A/B), parainfluenza (hPV), adenoviruses (hAdV), bocaviruses (hBoV), rhinovirus (hRV), coronaviruses (hCoV), respiratory-syncytial (hRcV) and metapneumovirus (hMpV).Viral pathogens were identified in 57,5% of patients with IE BA. The greatest significance of the etiological agents of viral IE BA had hRV - in 52,2% of cases. Much less frequently detected hBoV - in 13,0% of cases; hMpV - at 8,7%; hRcV - at 6,5%; hCoV, hAdV, hPV, influenza A that B - 4% each.In patients with IE of BA viral pathogens have been identified mainly in the winter-spring period in Dec and Feb - in 32,5% of patients, in Mar and May - in 48,8%, which generally coincides with the seasonal acute respiratory tract infections period. It should be noted that during the investigation registered epidemic of flu was not reported.The frequency of detection of viral pathogens of IE of BA depended on the period from the start of illness. In the first three days of illness viral pathogens detection rate was 78,3%, a 4 - 7 day – 21,7%, on day 8 and later none of the viral pathogen detected.