@article {RubinsztajnP799, author = {Renata Rubinsztajn and Tadeusz Przybylowski and Marta Maskey-Warzechowska and Magdalena Paplinska-Goryca and Patrycja Nejman-Gryz and Krzysztof Karwat and Ryszarda Chazan}, title = {The influence of hyperinflation on body composition and cytokine profile in patients with COPD}, volume = {42}, number = {Suppl 57}, elocation-id = {P799}, year = {2013}, publisher = {European Respiratory Society}, abstract = {Body composition is an important prognostic factor in patients with COPD. The decrease in fat free mass (FFM), muscle mass (MM) and increase in visceral fat is associated with an elevated secretion of cytokines which promote systemic inflammation.Aim: to evaluate body composition and the cytokine profile in patients with COPD in relation with the presence of hyperinflation.The study group consisted of 149 patients with stable COPD aged 68{\textpm}8.8 yrs with a mean FEV1 55.9{\textpm}18.9 \% predicted. The patients underwent spirometry and bodypletysmography. Hyperinflation was defined as RV\%TLC \> 48\% and \> 126\% predicted. Body composition was analyzed by bioimpedance. The following serum inflammatory markers were evaluated: C-reactive protein, IL-6, IL-8, TNF alpha, CC16, adiponectin and resistin.Hyperinflation was found in 96 patients (group A), more frequently in women (49/61 vs. 47/88, p\<0.001).BMI and age in this group were comparable to those in patients without hyperinflation (group B). Table 1 presents significant differences in body composition between both groups.View this table:Table1We found significantly higher serum concentrations of IL-6, resistin and CRP in group A.Conclusions:1/ Although BMI is not different in COPD patients with and without hyperinflation, patients with hyperinflation have a lower FFM, TBW MM and a higher proportion of fat tissue.2/ Hyperinflation is associated with systemic inflammation and could therefore be a negative prognostic factor in COPD patients.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/P799}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/P799.full.pdf}, journal = {European Respiratory Journal} }