RT Journal Article SR Electronic T1 Serum miR-122 levels correlated to the coagulation disorders of severe sepsis patients JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P2438 VO 42 IS Suppl 57 A1 Huijuan Wanghuijuan A1 Jie Deng A1 Pengjun Zhang A1 Xin Zhang A1 Weijun Chen A1 Dan Feng A1 Yanhong Jia A1 Lixin Xie YR 2013 UL http://erj.ersjournals.com/content/42/Suppl_57/P2438.abstract AB Purpose: miR-122 is a serum signature for liver injury and a prognostic predictor for sepsis patients. Sepsis patients with coagulation abnormalities may be a major impact on the outcome. The aim of our study was to investigate if there were relations between miR-122 and coagulation disorder during sepsis.Methods: 123 severe sepsis patients were recruited from Intensive Care Units of Chinese PLA general hospital. 24 healthy subjects were selected as normal controls. After collection of the blood samples of these participants, levels of miR-122 were detected by quantitative reverse transcriptase polymerase chain reaction assays (qRT-PCR) and coagulation indexes were detected by Enzyme-Linked Immunosorbnent Assay (ELISA).Findings: Serum levels of miR-122 were correlated to the serum levels of Activated Partial Thromboplastin Time (APTT) (R=0.426, p=0.008), Fibrinogen (FIB) (R=0.398, p=0.008), Antithrombin III (AT III) (R=0.913, p<0.001). Then, these patients were divided into coagulation abnormal patients and coagulation normal patients. Levels of miR-122 were significantly higher in coagulation abnormal patients than in coagulation normal patients (p=0.029). The area under curve of miR-122 to diagnose coagulation abnormalities was 0.676 (95%CI, 0.533-0.819), p=0.029. When the relative level of serum miR-122 was 0.453, miR-122 generated a sensitivity of 59.4% and a specificity of 77.3%.Conclusions: Serum levels of miR-122 were correlated to coagulation disorders of sepsis patients.