RT Journal Article SR Electronic T1 Serum levels of IL-2, IL-4 in bronchopulmonary mycoplasma pneumoniae infection in children JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P1215 VO 42 IS Suppl 57 A1 Svetlana Sciuca A1 Liuba Neantu A1 Vera Magalu YR 2013 UL http://erj.ersjournals.com/content/42/Suppl_57/P1215.abstract AB Aim of our study was to evaluate changes of IL-2, IL-4 in peripheral blood in Mycoplasma pneumoniae infection of lower respiratory tract disease in children.Methods. The study included 33 children, aged 6 months - 7 years, with pneumonia and wheezing. Levels of Mycoplasma pneumoniae-specific antibodies (IgM, IgG) were determined in serum samples obtained from all 33 children that were tested by ELISA. The peripheral blood concentrations of IL-2, IL-4 were measured by ELISA.Results. 20 patients completed study group with Mycoplasma-positive infection (levels of specific IgM was 0,73±0,13, cut-off 0,65±0,02 and IgG was 1,19±0,13, cut-off 0,53±0,02) and 13 children completed control group Mycoplasma-negative infection (levels of specific IgM was 0,29±0,04, cut-off 0,66±0,05 and IgG was 0,26±0,04, cut-off 0,5±0,03). IL-2 levels in children with Mycoplasma-positive bronchopulmonary disease was 31,80±2,26 pg/ml and in Mycoplasma-negative group 39,27±3,17 pg/ml, IL-4 levels was 46,92±2,93 pg/ml versus 52,36±2,17pg/ ml, respectively. Levels of IL-2 in our study group had decreased in comparison with control group (p<0,05) and it can suggest an insufficiency of mechanisms of T-cell mediated immunity in Mycoplasma pneumoniae infection in childhood bronchopulmonary diseases.Conclusion. One of the main pathogenic mechanisms in pulmonary disease produced by Mycoplasma pneumoniae in acute phase in children is the imbalance of served disorders of immune response with significant decreasing levels of IL-2.