@article {CastroPP116, author = {Margarida Castro and Andreia Matos and Jos{\'e} Albuquerque and Joana Ferreira and Manuel Bicho}, title = {LSC 2013 abstract - The role of beta2 adrenergic receptor polymorphism in asthmatic patients}, volume = {42}, number = {Suppl 57}, elocation-id = {PP116}, year = {2013}, publisher = {European Respiratory Society}, abstract = {It is known that beta2 adrenoreceptor polymorphisms could lead to a genotype-specific response to treatment and different asthma phenotypes.The purpose of this study is to analyse the association between Arg16Gly (rs1042713) and Gln27Glu (rs1042714) polymorphism with asthma severity. Asthmatic patients (n= 49) were studied for these polymorphisms by PCR-RFLP (Polymerase chain reaction- restriction fragment length polymorphism). Control of asthma assessed by validated instrument (ACQ7 and PAQLQ). Statistical analysis was performed with PASW version 18 establishing a significance level of p\< 0.05. The mean age of the 49 asthmatics was 35.59 {\textpm} 20.519 (7 -72 years); 24 females and 25 males; 41 atopics and 8 non-atopics; 32 with controlled and 17 with uncontrolled asthma. In asthmatics for Arg16Gly polymorphism, the frequencies of the allele A is 66.3\% and the allele G is 33.7\%; and for the Gln27Glu polymorphism, the frequencies were for allele C 30.6\% and G 69.4\%. Genotypes in the asthmatics for Arg16Gly polymorphism were: AA: 38.8\%; AG: 55.1\%; GG: 6.1\% and for the Gln27Glu polymorphism were: CC: 10.2\%; CG: 40.8\%; GG: 49\%. In asthmatics for Arg16Gly and Gln27Glu polymorphisms, there is no statistical difference (p\>0.05) in genotypes: between atopics and non atopics; controlled and uncontrolled asthma; and in the different age-groups. The frequencies of genotype Arg16Gly polymorphism were statistical different between males and females, being the genotype carrying the allele G more frequent among males (p = 0,039).In this study sample we were not able to demonstrate an influence of Gln27Glu and Arg16Gly beta-2 receptor gene polymorphisms on asthma severity.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/PP116}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/PP116.full.pdf}, journal = {European Respiratory Journal} }