@article {Arzt5035, author = {Michael Arzt and Anna Satzl and Andrea Hetzenecker and Kurt Debl and Andreas Luchner and Oliver Husser and Okka Hamer and Florian Poschenrieder and Claudia Fellner and Florian Zeman and G{\"u}nter Riegger and Michael Pfeifer and Stefan Buchner}, title = {Impact of sleep-disordered breathing on myocardial salvage and infarct size in patients with acute myocardial infarction}, volume = {42}, number = {Suppl 57}, elocation-id = {5035}, year = {2013}, publisher = {European Respiratory Society}, abstract = {Background: SDB may be a risk factor for expansion of infarct size early after acute MI by exposing the heart to repetitive oxygen desaturations and increased cardiac afterload.Objectives: The objective of this study was to assess the impact of sleep-disordered breathing (SDB) on myocardial salvage and infarct size within three months after acute myocardial infarction (MI).Methods: Patients with acute MI and percutaneous coronary intervention were enrolled in this prospective observational study. All patients underwent cardiovascular magnetic resonance (CMR) to define salvaged myocardium and infarct size within 5 days and at three months after acute MI. Patients were stratified according to apnea-hypopnea-index (AHI) assessed by polysomnography at baseline into those with (AHI >=15/h) and without (AHI \<15/h) SDB.Results: Of the 56 patients included, 29 (52\%) had SDB. The area at risk between both groups was similar (40{\textpm}12\% vs 40{\textpm}14\%, p=0{\textbullet} 925). Patients with SDB had significantly less salvaged myocardium (myocardial salvage index 52\% vs 77\%, p\<0{\textbullet} 001), smaller reduction in infarct size (0{\textbullet} 3\% vs 6{\textbullet} 5\%, p\<0{\textbullet} 001) within three months after acute MI, a larger final infarct size (23\% vs 12\%, p\<0{\textbullet} 001) and a lower final left ventricular ejection fraction (48\% vs 54\%, p=0{\textbullet} 023). In a multivariate analysis including established risk factors for large MI, AHI was independently associated with less myocardial salvage and a larger infarct size three months after acute MI.Conclusions: SDB was associated with less myocardial salvage and a smaller reduction in infarct size. These findings suggest a contribution of SDB to impaired healing of MI.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/5035}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/5035.full.pdf}, journal = {European Respiratory Journal} }