RT Journal Article
SR Electronic
T1 Relationship between the influence of exposure to tobacco smoke and max-IMT, ABI, ratio of EPA / AA in COPD patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2094
VO 42
IS Suppl 57
A1 Akinori Ebihara
A1 Akifumi Watanabe
A1 Asuka Nagai
A1 Takayuki Nakano
A1 Tokuzen Iwamoto
A1 Ichiro Kuwahira
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P2094.abstract
AB [Background]COPD is positioned as a systemic inflammatory disease. We have previously reported that COPD from early exposure to tobacco smoke may cause an increase of maximum value of the intima media thickness (max-IMT) that correlates with the increase in the prevalence of smoke-related vascular comorbidities. Analyzing the data of the ratio of serum Eicosapentaenoic Acid to Arachidonic Acid (EPA/AA) and Ankle Brechial Pressure Index(ABI), which were useful as an indicator of arteriosclerosis, we examined the correlation between them in this study. [Methods]We identified potential subjects from Erimo town clinic into two groups: G1) history of COPD and sever exposure to tobacco smoke; G2) subjects without COPD and analyzed the measurements max-IMT, EPA/AA and ABI. We defined severe smoke as that Brinkman Index more than 600. [Results]A total of 118 subjects (male 77, female 41) were enrolled into the study after informed consents were obtained. G1 and 2 consisted of 60 subjects (46, 14), 58 subjects (31,27), respectively. Max-IMT in G1 was 1.52 ± 1.29 mm, G2 was 1.38 ± 1.55mm. ABI in G1:G2 (0.84±1.23: 0.92±1.73), EPA / AA in G1: G2 (0.44± 0.37: 0.47±0.23). G1 had higher max-IMT when compared with G2. Furthermore, G1 demonstrated significant decline in ABI and EPA/AA, when compared with G2. [Conclusions]In subjects with COPD, sever exposure to smoke in addition to rise in max-IMT, declined ABI and EPA/AA, that promoted atherosclerotic changes, which may increase the likelihood of smoke-related vascular comorbidities such as cardiovascular and cerberovascular diseases.