RT Journal Article
SR Electronic
T1 Sleep desaturation and pulmonary hypertension determine sleep-related quality of life and depression in idiopathic pulmonary fibrosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P466
VO 42
IS Suppl 57
A1 Likurgos Kolilekas
A1 Effrosyni Manali
A1 Panagiotis Lyberopoulos
A1 Katerina Vlami
A1 Christina Triantafillidou
A1 Konstantinos Kagouridis
A1 Sotirios Gyftopoulos
A1 Konstantinos Vougas
A1 Mina Gaga
A1 Anna Karakatsani
A1 Manos Alchanatis
A1 Spyros Papiris
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P466.abstract
AB Background Sleep breathing disorders are common in IPF and quality of life (QOL) and sleep (QOS) is poor.Aim To examine the impact of clinical, functional, physiological, cardiac and sleep parameters of IPF-OSA on QOL, QOS and depression and to evaluate the role of QOL-QOS and depression in survival.Patients and Methods IPF/UIP patients were prospectively studied and followed-up for survival. They performed pulmonary function test, the Epworth sleepiness scale-ESS, cardiac ultrasound, maximal exercise test (CPET),nocturnal polysomnography, evaluation of a. functional status outcomes and quality of life associated with sleepiness by the Functional Outcome of Sleep Questionnaire (FOSQ), b.of sleep difficulty and physical and mental functioning by the Athens Insomnia Scale (AIS) c. severity of depression by the Beck Depression Inventory (BDI).Results Twenty eight patients (78.6 % male), of 68.4 (± 7.9) years, BMI of 28.6 (± 4.3), ESS of 6.6 (± 3.82), with IPF and AHI>5 were examined. AHI was 16.3 [IQR 7.5-21.3]. FOSQ, AIS and BDI were 0.79 (± 0.2), 0.22 (± 0.2) and 9.13 (± 5.7). MinSaO2 during sleep and maxdiffSaO2 awake-sleep was 81.8±7.3 and 10.7±5.7. FVC%, TLC% and DLCO% values were at 77±17.9, 63.5±12.8 and 43.5±15.6. VO2 peak/kg and SaO2 peak at CPET were 17.0 ml/min/kg±4.1 and 88.4±6.0. RVSP was 35.3±12.4 mmHg. Median survival was 520 days. Significant associations were found between MinSaO2 during sleep, maxdiffSaO2 awake-sleep and RVSP with FOSQ, AIS and BDI. Conclusion IPF-OSA patients present impaired quality of life and sleep and mild to moderate depression significantly related with sleep oxygen desaturation and pulmonary hypertension.