RT Journal Article SR Electronic T1 Longitudinal changes in regular physical activity (PA) in subjects with and without COPD: Findings from the Copenhagen City heart study JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1984 VO 42 IS Suppl 57 A1 Anouk W. Vaes A1 Judith Garcia-Aymerich A1 Peter Lange A1 Marta Benet A1 Jacob L. Marrot A1 Frits M.E. Franssen A1 Jørgen Vestbo A1 Emiel F.M. Wouters A1 Peter Schnohr A1 Martijn A. Spruit YR 2013 UL http://erj.ersjournals.com/content/42/Suppl_57/1984.abstract AB Background To date, little is known about longitudinal changes in PA in subjects with and without COPD. Therefore, we aimed to determine whether and to what extent regular PA may change over time in a large cohort of subjects with and without COPD.Methods Subjects of the Copenhagen City Heart Study with at least 2 consecutive observations (time interval: 5 to 10 yrs) were selected. PA level was measured using a questionnaire. Subjects were stratified according to baseline PA into three groups: low (light PA such as walking or biking for <2 hrs/wk), moderate (light PA for 2-4 hrs/wk), or high (light PA for >4 hrs/wk or more vigorous activity for > 2hrs/wk).Results Data of 1,270 subjects with COPD (58% men, 56±10 yrs, FEV1: 67±18%pred) and 8,734 subjects without COPD (42% men, 49±13 yrs, FEV1: 91±15%pred) were used, resulting in 16,659 repeated observations (with COPD: 1,733; without COPD: 14,926). The proportion of subjects with COPD with moderate/high baseline PA who had a decline in PA during follow up, was significantly higher compared to subjects without COPD with similar baseline PA (p<0.05, Table 1). These differences remained significant after correction for age and gender.View this table:Table 1. Changes in PA levelConclusion Longitudinal decrease in PA occurs more often in subjects with COPD. Therefore, PA needs to be assessed and stimulated by healthcare providers in subjects with COPD.This study was financially supported by 'Stichting De Weijerhorst'.