TY - JOUR T1 - Do patients with recurrent exacerbations of COPD requiring NIV receive higher pressures than those that are NIV naive? JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P4751 AU - Edward A. Benison AU - W.Y. Ding AU - Emma Houston AU - Mithun Murthy AU - Rajesh Yadavilli AU - Hassan Burhan Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P4751.abstract N2 - IntroductionNon-Invasive Ventilation (NIV) is a well established treatment for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) with acidotic type 2 respiratory failure (T2RF). Many patients have recurrent AECOPD requiring repeated NIV.ObjectiveTo assess whether patients with prior history of NIV for AECOPD receive higher inspiratory positive airway pressure (IPAP) than those that receive NIV for the first time.MethodsData was collected prospectively from 28 patients admitted to the NIV unit at the Royal Liverpool Hospital. 14 patients had received NIV at least once before and 14 had not received NIV prior to this episode.ResultsSee Table 1. There were 3 in-patient deaths in each group. Mean (SD) length of stay (LOS) was 13.2 (10.6) days for those that had previously received NIV and 13.9 (19.5) days for those that had not.View this table:Table 1ConclusionsPatients that had received NIV on prior admissions had higher initial and 12-hour IPAP but this did not lead to a greater improvement in pCO2 or pH at 12 hours into NIV. The mean time to normalisation of pH and LOS were, however, shorter. None of the differences between the two groups reached statistical significance. This may be due to these patients having a poorer functional status or more severe disease. There was, perhaps surprisingly, no difference in survival between the two groups. ER -