PT - JOURNAL ARTICLE AU - Ali Kocabas AU - Gulsah Derinkuyu AU - Mujde Cigerli Ocak AU - Gulsah Seydaoglu AU - Ezgi Ozyilmaz TI - The relationship between systemic inflammation and vitamin D levels in COPD DP - 2013 Sep 01 TA - European Respiratory Journal PG - P4219 VI - 42 IP - Suppl 57 4099 - http://erj.ersjournals.com/content/42/Suppl_57/P4219.short 4100 - http://erj.ersjournals.com/content/42/Suppl_57/P4219.full SO - Eur Respir J2013 Sep 01; 42 AB - Introduction:A number of reports showed that vitamin-D levels effect systemic inflamation in chronic diseases.However, the relationship between systemic inflamation and vitamin-D levels in COPD has not been elucidated yet.The aim of this study is to evaluate the link between serum vitamin-D levels and systemic inflammation markers in patients with COPD.Methods:Fifty stable COPD patients who were admitted to Cukurova University Faculty of Medicine Department of Pulmonary Disease outpatient clinic and fifty-one healthy control subjects were recruited for the prospective study. After obtaining clinical and demographical information, respiratory function tests, 6-minute walking tests were performed. BODE index, physical activity level and mMRC dyspne scores were measured. Peripheral venous blood samples were taken for measurement of serum 25-OH vitamin-D3 levels and systemic inflammatory markers including IL-1, IL-6, IL-8, TNF-Alpha, CRP and fibrinojen.Results:Serum mean vitamin-D levels were lower in COPD patients then control subjects (19.8±6.2 vs 28.4±8.1ng/ml,p<0.001) and the prevelance of vitamin-D defiency(<=20ng/ml) were more prominent in COPD patients then controls (46% vs 11.5%,p<0.001). When the COPD patients with and without vitamin-D deficiency compared, serum inflammatory markers were comparable. As well, no significant correlation was found between serum inflammatory markers and serum vitamin-D levels.Conclusion:This study showed that vitamin D defiency is frequent in COPD however no correlation was detected between serum vitamin D and systemic inflammation biomarkers. Further clinical trials about systemic inflammation-vitamin-D relationship are needed on stable and exacerbated COPD patients.