TY - JOUR T1 - The influence of type of inhalation device on adherence of COPD patients to inhaled medication JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P4146 AU - Kirsten Koehorst-ter Huurne AU - Kris Movig AU - Paul vanderValk AU - Job van der Palen AU - Marjolein Brusse-Keizer Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P4146.abstract N2 - Objective: To study the influence of type of inhalation device on adherence of COPD patients to inhaled medication.Methods: Therapy adherence of 795 patients was recorded from pharmacy records over 3 years. It was expressed as percentage and was deemed good at 75–125%, sub-optimal 50-75%, and poor <50% or >125%. Some patients used more than one medication, so we present 1377 medication periods.Results: Patients using a Cyclohaler have a 7-fold increased risk of suboptimal adherence versus good adherence compared to the Handihaler; for Metered Dose Inhaler (MDI) and Diskus 2.3 and 2.2 times as high, respectively. (table 1)Patients using a MDI, Diskus or Autohaler have a 2.0; 2.2 and 6.8-fold increased risk of poor <50% versus good adherence compared to a Handihaler. Patients using a MDI, Autohaler, Turbuhaler or Cyclohaler have an increased risk of poor (>125%) versus good adherence compared to a Handihaler.View this table:Table 1: Nominal regression of device vs therapy adherence. Good adherence and Handihaler are set as reference. Corrected for FEV1 at baseline.Conclusions: Handihaler showed the highest adherence. MDI, Autohaler, Turbuhaler and Cyclohaler have a higher risk of overuse compared to Handihaler. MDI, Diskus and Autohaler show an increased risk of underuse. ER -