TY - JOUR T1 - Impact of hyperglycaemia and comorbid diabetes mellitus on short and long-term outcome after COPD exacerbation JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P4186 AU - Aran Singanayagam AU - Peter Williamson AU - Philip Short AU - Ahsan Akram AU - Louise Peet AU - Sarah Higgins AU - Stuart Schembri AU - James Chalmers Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P4186.abstract N2 - BackgroundThe effect of hyperglycaemia on outcome following acute exacerbation of COPD (AECOPD) is unclear and may be confounded by several factors including comorbid diabetes mellitus (DM) and prior oral corticosteroid (OCS) use. The aim of this study was to evaluate the effect of hyperglycaemia and DM on short and long-term outcomes following hospitalised AECOPD.Methods We conducted a multi-centre prospective observational study assessing patients hospitalized with AECOPD. All patients had serum glucose measured on admission. Outcomes of interest were 30 day and 1 year mortality.ResultsThere were 1069 patients included. Diabetes was significantly more frequent in the moderate and severe hyperglycaemia groups but there was no significant difference in OCS use prior to admission. Table 1 shows 30 day mortality according to glycaemic level, adjusted for a number of potential confounders including OCS use, in all patients and in non-diabetics.View this table:Hyperglycaemia was not significantly associated with any alteration in 1 year mortality but comorbid DM was associated with significantly reduced 1 year mortality (HR 0.68 (0.46-0.97); p=0.047).ConclusionSevere hyperglycaemia is associated with increased short-term mortality following AECOPD independently of comorbid DM and prior OCS use. Comorbid DM is associated with improved long-term outcome. ER -