@article {W{\"u}rtzP998, author = {Else Toft W{\"u}rtz and Tine Malling and Vivi Schl{\"u}nssen and Jens Georg Hansen and Charlotte Brach Andersen and {\O}yvind Omland}, title = {Occupational COPD among Danes aged 45 to 84 years: A populationon based study}, volume = {42}, number = {Suppl 57}, elocation-id = {P998}, year = {2013}, publisher = {European Respiratory Society}, abstract = {Aim. To analyse for occupational COPD among 4747 subjects aged 45 to 84 years in a cross-sectional populational based study.Method. The subjects were recruited from 155 general practices from two Danish counties in 2004-06. Stratified sampling recruited 3111 males and 1636 females from the Danish Civil Registration System to the study. COPD was defined when measured FEV1/FVC z-score was below 2 standard deviations based on LLN criteria. From questionnaire a smoking and occupational history was obtained. DISCO-88 was used together with expert derived assessment to define occuptional exposure in jobs where vapour, gas, dust (organic and inorganic), and fume (VGDF) were a risk factor. Low exposure was defined as 0-4 years in a job, medium 5-14 years, and high >= 15 years.Results. Of 372 DISCO-88 codes 72 were identified with high exposure to VGDF, 34 for organic dust, 20 for inorganic, 7 for both inorganic dust and fume, 5 for vapour, 3 for fume, 2 for both organic- and inorganic dust, 1 for inorganic dust, fume, and vapour. 28\% of the participants had a high exposure for VGDF. Adjusted for smoking, increased risk of COPD was found among workers in jobs with DISCO-88 codes with high exposure for organic dust OR 1.79 (95\% CI 1.35-2.36). However, for workers in jobs with DISCO-88 codes with high exposure for inorganic dust OR 0.75 (95\% CI 0.45-1.36), fume OR 1.20 (95\% CI 0.70 - 2.04), and vapour OR 0.76 (95\% CI 0.23 - 2.46) no increased risk were observed. We observed a dose-response relationship in organic dust exposure.Conclusion. Controlled for smoking increased risk for COPD was observed among subjects in jobs with DISCO-88 codes with high exposure for organic dust in a dose response fashion.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/P998}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/P998.full.pdf}, journal = {European Respiratory Journal} }