@article {HuangP697, author = {Xinyan Huang and Xiuyun Liu and Yifeng Luo and Yuqi Zhou and Yubiao Guo and Canmao Xie}, title = {Efficacy of tiotropium bromide inhalation combined with or without low dose theophylline for moderate to severe stable Chinese COPD patients}, volume = {42}, number = {Suppl 57}, elocation-id = {P697}, year = {2013}, publisher = {European Respiratory Society}, abstract = {Objective: To investigate and compare the efficacy of Tiotropium Bromide Inhalation combined with or without low dose oral theophylline (200mg/day) in moderate to severe Chinese COPD patients.Method: In this double-blind, multiple units, randomized clinical trial, 60 patients with moderate to severe stable COPD were recruited in Outpatient Department of Pulmonary Medicine in the First and Third Affiliated Hospital of Sun Yat-sen University from 2011 to 2012. After a two-week washout period, these patients were randomized into two groups, combination treatment group (n=30) and monotherapy control group (n=30). The treatment group was treated with Tiotropium Bromide Inhalation (18ug once per day) combined with low dose oral theophylline (200mg/day) for 6 months, while the control group was treated with Tiotropium Bromide Inhalation (18ug once per day) with placebo of oral theophylline. Pulmonary function, dyspnea score, 6-minute walk distance and the quality of life were measured before and after 6 months treatment course.Results: After 6 months of treatment, pulmonary function included FEV1, FVC, FEV1/FVC(\%) and exercise tolerance of treatment group improved significantly compared with the control group (P \<0.05). Dyspnea score by mMRC, the quality of life by SGRQ score in treatment group also showed significant improvement than the control group (P \<0.05).Conclusion: Compared with Tiotropium Bromide Inhalation monotherapy, Tiotropium Bromide Inhalation added on with low dose theophylline can improve pulmonary function, dyspnea score, exercise tolerance and quality of life much better in moderate to severe stable Chinese COPD patients.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/P697}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/P697.full.pdf}, journal = {European Respiratory Journal} }