RT Journal Article
SR Electronic
T1 The body mass index and chronic obstructive pulmonary disease in the BOLD study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4652
VO 42
IS Suppl 57
A1 Lowie Vanfleteren
A1 Bernd Lamprecht
A1 Emiel Wouters
A1 Louisa Gnatiuc
A1 Peter Burney
A1 Michael Studnicka
A1 Frits Franssen
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/4652.abstract
AB Background: Nutritional status is related to clinical outcome and prognosis in patients with COPD. However, the relation between the body mass index (BMI) and COPD has not been studied in the general population.Aims: To assess the relation between BMI and presence and severity of COPD in a general worldwide population, taking into account confounding factors.Methods: 13.774 participants (49% male, 23% current smokers, mean age: 56±11 years, mean BMI: 26.6±5.4kg/m2) in the Burden of Obstructive Lung Disease initiative were included. COPD was defined spirometrically as post-bronchodilator FEV1/FVC<LLN and further staged into stage 1 (FEV1>80%), stage 2 (FEV1 50-80%) and stage 3+ (FEV1<50%). Low BMI was defined as <21 kg/m2, obese BMI as >30 kg/m2.Results: Subjects were gradually more distributed towards a lower BMI with increase in COPD severity. (Figure) Odds ratios for low BMI (adjusted for age, gender and smoking) gradually increased with COPD stage compared to normal lung function (NLF) (1.4 (1.1-1.7); 2.0 (1.6-2.5); 5.0 (3.7-6.7) for stage 1, 2 and 3+ resp.). The adjusted odds for obesity were generally lower in COPD compared to NLF, although the odds were comparable in stage 2 COPD. (0.6 (0.5-0.8); 1.0 (0.8-1.2); 0.6 (0.4-0.9) for stage 1, 2 and 3+ resp.)Conclusion:In a general worldwide population the presence and severity of COPD is associated with a lower BMI. Although subjects with moderate COPD have equal odds for obesity.