RT Journal Article
SR Electronic
T1 Relationship between age and online nasal nitric oxide measured using different techniques in children with suspected primary ciliary dyskinesia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3424
VO 42
IS Suppl 57
A1 Nicole Beydon
A1 Arnaud Chambellan
A1 Véronique Nève
A1 Estelle Escudier
A1 Alberti Corinne
A1 Muriel Le Bourgeois
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P3424.abstract
AB Background Variable thresholds of nasal nitric oxide (nNO) are proposed to screen children for primary ciliary dyskinesia (PCD) without taking age into account. But very few young children have been studied in whom false positive were tests were found.Objectives 1) to study the relationship between age and nNO measured using apnea (AP) or expiration against resistance (ExRe), and the tidal breathing (VT) techniques in non PCD children.Methods Multicentre online nNO measurements study (chemiluminescence, Seres, France, Aerocrine, Sweden, flow sample 0.3L.min-1) in children with suspected PCD. Values recorded were the best value of AP or ExRe, and means of 5 maximal peaks, 10s during controlled regular VT, and last 30s during VT measurement.Results 79 children with complete diagnosis procedure (47 with PCD, age, median [range] 11.0 [3.2-17.8]y) were studied. In non PCD children, nNO measurement was correlated with age (AR or ExRe p=0.0002, r2 = 0.38; 5 peaks p<0.03, r2 = 0.17; 10s p<0.02, r2 = 0.22) (Figure). nNO values according to techniques are shown in table.View this table:ConclusionnNO thresholds value to discriminate for PCD cannot be independent of age in children whichever the nNO technique of measure used.