RT Journal Article
SR Electronic
T1 Persistent wheezing after bronchiolitis: 5 years of follow up
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4322
VO 42
IS Suppl 57
A1 Marianna Ferrara
A1 Giulia Cangiano
A1 Ambra Nicolai
A1 Stefano Papasso
A1 Federico Gentile
A1 Corrado Moretti
A1 Marianna Eleonora Grande
A1 Concetta Schiavariello
A1 Fabio Midulla
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P4322.abstract
AB Background: We have showed the association between Rhinovirus (RV) infection, atopic predisposition and recurrent wheezing 1 and 3 yrs after bronchiolitis.Aim: Identify risk factors for persistent wheeze 5 yrs after bronchiolitis.Material and methods: We enrolled 179 infants (median age 2 m, range 7 d -11 m) hospitalized for bronchiolitis during the period October 2004-May 2007. Demographic and clinical data were obtained from patient’s medical files. Parents were interviewed by phone with a structured questionnaire for 5 consecutive yrs. Five years after bronchiolitis 60 children performed lung function tests (LFT) and skin prick test (SPT).Results: 112 families (62,6%) answered. 35 children never had episodes of wheezing (NW) whereas 30 children presented episodes of wheezing each year for all 5 years (PW). The percentage of children with eosinophils >400 cells/µl was significantly higher in children with PW than in those who NW (0 vs 13.3%; p=0.02). 13,3% of children with PW had bronchiolitis from RV comparing to 2,8% of children who NW. 80% of infants with bronchiolitis from RV had PW, comparing to 34,8% of infants with bronchiolitis from Respiratory Syncytial Virus. 73,3% of children with PW was born by cesarean section (CS), comparing to 26,7% born by natural childbirth (p=0.07). The association between CS and PW was confirmed also by logistic regression analysis (p<0,05). No significant difference was observed for LFT and SPT results between PW and NW.Conclusions: Eosinophilia, RV infection and CS seem to be associated with PW after bronchiolitis.