@article {KamenovP4299, author = {Svetlana Kamenov and Aleksandar Kamenov and Snezana Cekic and Borislav Kamenov}, title = {Anti-inflammatory effect of low dose theophylline in school children with bronchial asthma}, volume = {42}, number = {Suppl 57}, elocation-id = {P4299}, year = {2013}, publisher = {European Respiratory Society}, abstract = {Background: Treatment with theophylline is important with the patients suffering from moderate bronchial asthma. Few studies have shown that the late asthmatic response to an allergen challenge is inhibited by theophylline.Methods: The objective of the research work is to point whether a low dose of theophylline has anti-inflammatory effect in asthma. We have analyzed a group of 30 asthmatic school children for 8 weeks. They received 125 mg theophylline twice daily. In all patients FEV1, symptom score, and reduction of the eosinophil number in the peripheral blood were determined.Results: After the treatment we noticed an increase of values of FEV1 from (71{\textpm} 3.2) to (96{\textpm} 2.1) improving symptom score (p\< 0.01) and eosinophil number in the peripheral blood reduction (p\< 0.01).Conclusion: During the treatment improvement of symptoms and lung function were noticed. Low dose theophylline is safe and has inhibitory effect on airway inflammation.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/P4299}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/P4299.full.pdf}, journal = {European Respiratory Journal} }