TY - JOUR T1 - Using the DOSE index to predict changes in health status and hospitalisation of COPD patients JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P265 AU - Lisette van den Bemt AU - Myrte Rolink AU - Wouter van Dijk AU - Saskia van den Haak - Rongen AU - Tjard Schermer Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P265.abstract N2 - BackgroundThe FEV1 is associated with increased mortality and used for severity classification of COPD worldwide. A multicomponent index – like the DOSE index - has the potential to predict important future outcome in patients with COPD better than the FEV1.Aims and objectivesThe aim of our study was to investigate if the DOSE index can predict which patients are at risk for a clinically relevant change in health status and hospitalisation (1).MethodsA prospective cohort study was done with data from primary care and secondary care. The DOSE score (dyspnea score (D), level of airflow obstruction (O), current smoking status (S) and exacerbations (E)) was determined at baseline and the 2-year change in Clinical COPD Questionnaire (CCQ)-score was calculated as well as COPD hospitalisation risk in the second year of follow-up. Linear regression analysis was performed for the effect of a high DOSE score (i.e. ≥4) on change in CCQ score. Chi-square was used to test difference in hospitalisation risk based on this DOSE cut-off point.ResultsThe study population consisted of 209 patients (112 patients from primary care). Overall a high DOSE score was a significant predictor for a change in CCQ score after 2 years (0.41, 95%CI; 0.13, 0.70), in particular in primary care patients. Significant more patients were hospitalised with a DOSE-score ≥4. (28.0%) compared to a lower DOSE score (2.7%; p<0.01).ConclusionsA DOSE score ≥4 has the ability to identify COPD patients with a greater risk on future worsening in health status and hospitalisation risk.1) Rolink M. et al. Using the DOSE index to predict changes in health status of COPD patients. Primary Care Respiratory Journal (In press). ER -