TY - JOUR T1 - Metabolic perfil in obese and non-obese OSA children JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P4283 AU - Silke Weber AU - Erico Moreira Silva AU - Sergio Trindade AU - Priscila Rocha AU - Marcos Pereira Filho Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P4283.abstract N2 - Introduction: OSA is a possible risk factor for metabolic syndrome even in children. Objectives: To examine the relationship between metabolic markers (glucose, insuline resistance and lipids) and SDB in children and the impact on quality of life. Methods: 89 children, aged 3-12 years, were matched into 4 groups: G1:non-obese OSA, G2:obese OSA G3-obese, G4 healthy control. OSA was definded by polysomnographic result. Quality of life was assessed by the OSA 18 questionnaire. Metabolic markers (glucose, insulin, total cholesterol, HDL, LDL, VLDL and TGL) were measured on a fasting morning blood sample and were compared in the 4 groups. Results: OSA 18 revealed the negative impact on quality of life in OSA children in the domains: sleep disturbance, physical suffering and caregivers concerns. OSA severity (IAHm) was similar for G1 and G2. Insuline, HOMA and Glucose/Insuline were highest for obese children (G2 and G3), independent of OSA diagnosis. Cholesterol showed no difference for the 4 groups, but HDL was higher in non-obese (G1, G4), triglycerides were higher in obese (G3). Conclusions: OSA causes impairment on quality of life in children. For this population, we found no impact of OSA on the metabolic markers. Obesity was determinant on metabolic dysfunction and insulin resistance. ER -