@article {AgaP4440, author = {Mohammed Aga and Rana El-Helbawy and Nesreen El-Helbawy and Nevean El-Sheak}, title = {Utility of quantitative analysis of urine lipoarabinomannan in the diagnosis of tuberculosis}, volume = {42}, number = {Suppl 57}, elocation-id = {P4440}, year = {2013}, publisher = {European Respiratory Society}, abstract = {Background Urinary lipoarabinomannan (LAM) detection is a promising approach for rapid diagnosis of active tuberculosis (TB) Objective: to assess the diagnostic accuracy of urine lipoarabinomannan (LAM) among tuberculous-infected patients either pulmonary or extra pulmonary. Methods This study was carried out on 85cases (46 male and 39 female) with active tubercular infection divided into three groups; Pulmonary (n=40), Extrapulmonary (n=30) and Disseminated tuberculosis (n=15) .Ten normal individual were included as control group. LAM level was measured in urine by enzyme- linked immunosorbant assay (ELISA). Results: The LAM antigen bind to Anti-LAM antibody from the urine in 69 out of 85 cases of active pulmonary and extra pulmonary TB. Patients with disseminated disease had a higher urine LAM level (1.75 {\textpm} 1.65 ng/ml) than that for patients with pulmonary (0.58 {\textpm} 0.53 ng/ml) or extra pulmonary TB (0.17 {\textpm} 0.11 ng/ml) (P\<0.001). Patients with smear positive specimens had a higher urine LAM level (0.63 {\textpm} 0.54 ng/ml) than that of smear negative (0.040 {\textpm} 0.06 ng/ml) (P\<0.001). Quantitative urine LAM test results positively correlate with degree of bacillary burden in patients with microbiologically confirmed TB, it was higher in high inoculums specimens (0.84 {\textpm} 0.49 ng/ml). Conclusion: Urine LAM test is rapid and reliable diagnostic modality for pulmonary or extra pulmonary TB.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/P4440}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/P4440.full.pdf}, journal = {European Respiratory Journal} }