TY - JOUR T1 - Impact of gender on disease activity, pulmonary function and health status in sarcoidosis patients - King's sarcoidosis questionnaire (KSQ) JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P413 AU - Branislav S. Gvozdenovic AU - Amit Suresh Patel AU - Surrinder S. Birring AU - Violeta Vucinic AU - Mira Vukovic Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P413.abstract N2 - Health status impairment in sarcoidosis has been shown to be worse in women. The aim of the study was to determine gender differences in health status, degree of dyspnea, and compare commonly used health status questionnaires.In a cross-sectional sample of 67 (43 female) sarcoidosis patients pulmonary function, serum ACE and health status were assessed. Health status was assessed using the disease-specific King’s Sarcoidosis Questionnaire (KSQ) with modular scores: General Health Status (GHS), Lung, Medication, Skin, Eyes and GHS–Lung score), the respiratory-specific St Georges Respiratory Questionnaire (SGRQ) and a Generic tool – 15D. Dyspnea was assessed using the MRC dyspnea scale.Women had significantly lower mean GHS scores (Med 59.9 vs. 83.96, p=0.001) and GHS–Lung scores (Med 66.04 vs. 88.68, p=0.013), as well as higher MRC scores (Med 1 vs. 0, p=0.011). There was no significant difference in SGRQ Total scores (p=0.117) or 15D scores (p=0.055) between men and women. Serum ACE was significantly higher in women (18/43), than in men (4/20) perhaps suggesting more active disease. KCO (%) values were significantly lower in women in comparison with men (Med 89.5 vs. 103, p=0.036) suggesting more severe pulmonary impairment. There were no significant differences in other pulmonary function tests.In this cohort of patients sarcoidosis in women was associated with greater dyspnea, a more frequent active inflammatory process and lower lung diffusion tests in comparison with men. In comparison to the SGRQ and 15D, the KSQ discriminates worse health status significantly better in sarcoidosis patients. ER -