RT Journal Article
SR Electronic
T1 Sleep apnea in acromegaly
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4043
VO 42
IS Suppl 57
A1 Muhammed Emin Akkoyunlu
A1 Mahmut Muzaffer Ilhan
A1 Mehmet Bayram
A1 Ertugrul Tasan
A1 Hatice Özçelik
A1 Fatmanur Karaköse
A1 Fatih Yakar
A1 Levent Kart
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P4043.abstract
AB BackgroundSleep Apnea Syndrome (SAS) is a frequent condition in acromegalic patients which causes mortality and morbidity. While some studies show that treatment of acromegaly may regress SAS even may eliminate, however other studies claim that hormonal withdrawal is not effective in reducing pathology especially if permanent structural changes have occurred. In our study, we aimed to search SAS prevalence in acromegaly patients and changes in SAS after acromegaly treatment.Material and MethodForty two acromegaly patients who admitted to Endocrinology Department of Bezmialem Vakif University were included to the study. Demographic properties, body measurements, time of disease, Growth hormone levels, IGF, blood glucose levels, drugs in use were recorded and night polisomnography were performed. Treatment started to 22 newly diagnosed and/or uncontrolled patients. Of these, 14 had diagnosed SAS and control polisomnograhy were performed 6 months after disease control has achieved.ResultsWhile 15 patients were newly diagnosed, 20 patients were under control and 7 were out of control. SAS present in 52% (n:22) of all cases, 35% (n:7) of under control patients, 71% (n:5) of out-of-control group and 66% (n:10) of newly diagnosed patients. Two patients had no SAS in the control polisomnograhy of 14 patients. Respiratory Distress Index (RDI) was significantly lower in the control polisomnograhy (p:0.015).ConclusionSAS risk is increased in acromegaly patients. Although, SAS severity was decreased after treatment and complete recovery was present in limited cases, probable permanent structural changes lead to incomplete SAS recovery in most of the cases.