PT  - JOURNAL ARTICLE
AU  - Muhammed Emin Akkoyunlu
AU  - Mahmut Muzaffer Ilhan
AU  - Mehmet Bayram
AU  - Ertugrul Tasan
AU  - Hatice Özçelik
AU  - Fatmanur Karaköse
AU  - Fatih Yakar
AU  - Levent Kart
TI  - Sleep apnea in acromegaly
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P4043
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P4043.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P4043.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - BackgroundSleep Apnea Syndrome (SAS) is a frequent condition in acromegalic patients which causes mortality and morbidity. While some studies show that treatment of acromegaly may regress SAS even may eliminate, however other studies claim that hormonal withdrawal is not effective in reducing pathology especially if permanent structural changes have occurred. In our study, we aimed to search SAS prevalence in acromegaly patients and changes in SAS after acromegaly treatment.Material and MethodForty two acromegaly patients who admitted to Endocrinology Department of Bezmialem Vakif University were included to the study. Demographic properties, body measurements, time of disease, Growth hormone levels, IGF, blood glucose levels, drugs in use were recorded and night polisomnography were performed. Treatment started to 22 newly diagnosed and/or uncontrolled patients. Of these, 14 had diagnosed SAS and control polisomnograhy were performed 6 months after disease control has achieved.ResultsWhile 15 patients were newly diagnosed, 20 patients were under control and 7 were out of control. SAS present in 52% (n:22) of all cases, 35% (n:7) of under control patients, 71% (n:5) of out-of-control group and 66% (n:10) of newly diagnosed patients. Two patients had no SAS in the control polisomnograhy of 14 patients. Respiratory Distress Index (RDI) was significantly lower in the control polisomnograhy (p:0.015).ConclusionSAS risk is increased in acromegaly patients. Although, SAS severity was decreased after treatment and complete recovery was present in limited cases, probable permanent structural changes lead to incomplete SAS recovery in most of the cases.