RT Journal Article
SR Electronic
T1 Cardiovascular autonomic alterations and severity of the disease in community-acquired pneumonia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2764
VO 42
IS Suppl 57
A1 Eleonora Tobaldini
A1 Stefano Aliberti
A1 Vanessa Nunziata
A1 Giulia Suigo
A1 Alice D'Adda
A1 Fabio Giuliani
A1 Giulia Bonaiti
A1 Andrea Roveda
A1 Alberto Pesci
A1 Nicola Montano
A1 Francesco Blasi
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P2764.abstract
AB No data evaluated cardiovascular autonomic control (CAC) in community-acquired pneumonia (CAP). Aim was to describe CAC according to the severity of CAP. Patients hospitalized in two university hospitals from Sept. 2011 to Jan. 2013 for CAP underwent 15' registration of ECG and respiration within 24 hours after admission. CURB65, gas exchange and the presence of severe CAP (sCAP ATS 2007) were recorded on admission. CAC was assessed using spectral (SP) and symbolic (SY) analysis of heart rate variability (HRV). SP evaluates rhythmical components of HRV identifying two oscillations: low (LF) and high (HF) frequency components, markers of sympathetic and vagal modulation, respectively. SY identifies two indices, 0V% and 2UV%, indices of sympathetic and vagal modulation, respectively. 58 patients (33 males; median age: 74 yrs) were enrolled. sCAP patients showed a higher HR (p=0.036), lower 0V% and higher 2UV% compared to patients without sCAP. Patients with CURB65 score≥3 were characterized by lower LFnu compared to patients with CURB65<3. Patients with a PaO2/FiO2 ratio<200 showed a higher 2UV% compared to those with a PaO2/FiO2 ratio≥200.View this table:CAP patients with a severe disease on admission show a relatively predominant vagal modulation associated with an altered sympathetic modulation, possibly due to the loss of rhythmical properties of sympathetic outflow.