TY - JOUR T1 - Association between airflow obstruction and arterial stiffness JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P3442 AU - Hisamitsu Omori AU - Masako Oda AU - Ayumi Onoue AU - Noritaka Higashi AU - Yasuhiro Ogata AU - Takahiko Katoh Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P3442.abstract N2 - Background: Smokers with airflow obstruction have exaggerated atherosclerosis. To date, limited data exist on airflow obstruction (COPD) and atherosclerosis in Japan.Aims and objectives: The objective was to assess the association between airflow obstruction and arterial stiffness assessed by measurement of pulse wave velocity (PWV).Methods: This cross-sectional study included 849 subjects (mean age 61.3 years (SD 11.9), range 31-89), who underwent a comprehensive health screening containing spirometry, measurement of brachial-ankle pulse wave velocity (ba PWV), and blood sampling at a medical check-up in 2009 at Japanese Red Cross Kumamoto Health Care Center. Airflow obstruction (AO) was defined according to Global Institute for Chronic Obstructive Lung Disease (GOLD) criteria (FEV1/FVC<0.7).Results: Mean (SD) ba PWV was greater in subjects with AO, 1734.6 (427.5) cm/sec, than in subjects without AO, 1564.9 (322.0) cm/sec, p<0.001. In logistic regression models adjusted for sex, age, smoking habits, hypertension treatment, dyslipidemia treatment, and diabetes treatment, higher ba PWV (greater than 1400 cm/sec) were significantly associated with AO compared to without AO (OR: Odds ratio, 2.12; 95%CI: 95% Confidence intervals, 1.27-3.55). Conclusions: Our study suggested that subjects with AO would have increased arterial stiffness. ER -