PT  - JOURNAL ARTICLE
AU  - Alena Zhuiko
AU  - Marina Gertcen
AU  - Eugen Atroschenko
TI  - Right ventricular diastolic function in patients with COPD and heart failure, depending on endothelial function
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P2496
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P2496.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P2496.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Introduction: Endothelial dysfunction is one of the key factors in the development of pulmonary hypertension in patients with COPD. Cardiovascular disease is the most common comorbidity in patients with COPD.Objective: To study the right ventricular (RV) diastolic function in patients with COPD and concomitant heart failure (CHF), depending on the endothelial function.Methods: A total of 67 patients (mean age, male 59,6±0,9 years) after myocardial infarction (experience 4,97±0,42 years; FEV1/FVC 66,7±1,6%). Vasoconstrictor response of endothelium found in 18 patients - I group, the reduced endothelium-dependent vasodilatation (EDV) in 26 persons-II group, normal EDV in 23 people -III group.Results: The isovolumic contraction time of RV increased more on 46 % (p =0,005) and the index of myocardial performance increased more on 11 % (p =0,01) in group I on contrast patients to the patients of group III. Ejection time (ET) of RV reduced to 11,5 % (p =0,003) in group II on contrast to the patients of group III. We’re not found significant differences of diastolic RV function between patients with impaired endothelial function and vasoconstriction.Conclusion: Impaired endothelial vasodilation in patients with concomitant diseases (COPD and CHF) is accompanied by worsening of RV diastolic function, the greatest changes were found in patients with endothelial vasoconstrictor response.