TY - JOUR T1 - Desquamative interstitial pneumonia: Follow-up of 17 patients JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2375 AU - Lubov Novikova AU - Yulia Ilkovich AU - Dali Dzadzua AU - Alexandra Speranskaya AU - Ivetta Dvorakovskaya AU - Marina Kameneva Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2375.abstract N2 - Desquamative interstitial pneumonia (DIP) according to ATS\ERS consensus statement belongs to Idiopathic Interstitial Pneumonia group.Materials, methods. We observed 17 patients with DIP: 5 male, 12 female, mean age - 38±5.4 years. 3 patients were smokers (0,2). The diagnosis was established histologically in 15 cases (0,9). The average duration of follow-up was 73,4 ±19,9 months.Results. The beginning of the disease was acute, the most common symptoms were: rapid progressing inspiratory dyspnea (1,0), unproductive cough (0,6), recurrent fever (0,6), arthralgias (0,2), weight loss (average 5,7±1,2 kg) - 0,6. Medical examination revealed cyanosis in 8 patients (0,5), early inspiratory crackles in 7 cases (0,4), nail clubbing in 3 patients (0,2). On CT scan bilateral widespread ground glass opacities were observed, in 3 cases with areas of honeycomb formation. Routine spirometry and lung volume measurement confirmed restriction and lung diffusion decrease.The therapy with corticosteroids was held, the initiating dose was 1 mg of prednisolone for each 1 kg of weight, in 15 cases as monotherapy, in 2 cases along with azathioprine.The patients’ conditions were monitored through time. One patient died of progressing respiratory failure, but in rest cases (0.9) the treatment was effective. In a year positive clinical, radiographic and functional changes were observed in 16 cases.View this table:Physiologic changes in DIP at presentation and in one year of treatment.Conclusion. DIP is characterized by acute onset, rapid progression, but favorable prognosis when treated with corticosteroids. ER -