TY - JOUR T1 - The link between nocturnal desaturation, HR and overall heart rate variability in severe asthma patients JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2024 AU - Yira Feshcheko AU - Liudmila Iashina AU - Irina Chumak AU - Svetlana Ishchuk AU - Liudmila Savelieva AU - Inna Zvol Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2024.abstract N2 - Aim of the investigation - to evaluate the correlation between the minimum SaO2 and average HR during the night and overall heart rate variability in patients with severe asthma.Materials and methods: 60 severe BA patients (27 male and 33 female aged from 24 to 83 years), FEV1 - (56,4 ± 2,0)% were studied with the use of Holter ECG monitoring and measurement of SaO2 during the night.The results of the investigation. SaO2 was measured during the whole night, and determined the minimum SaO2 per night - (84,1 ± 1,2)%, average HR per night was (66,7 ± 1,8)%, SDANN (standard deviation of the average duration of NN intervals during 5-minute intervals) - (120,7 ± 6,5) ms. In the course of correlation analysis the presence of statistically significant (p <0,05) inverse connection between HR during the night and min.SaO2 per night (r -3,371) and direct connection between SDANN and SaO2 (r 2,114) was revealed.Conclusion: Decreased SaO2 increases HR and decreases SDANN, indicating a decrease in the total variability of heart rate in this group of patients, reducing the activity of parasympathetic division of autonomic nervous system, which indirectly reflects the increased risk of cardiovascular disease, in particular the vitally unsafe arrhythmias. ER -