PT  - JOURNAL ARTICLE
AU  - Carlos Disdier Vicente
AU  - Dagoberto Bejarano Ugalde
AU  - Hipólito Gutiérrez García
AU  - María Henar Borrego Pintado
AU  - Jose María Matilla González
AU  - Rafael López Castro
TI  - OCT in bronchoscopic diagnosis and treatment of preinvasive endobronchial lesions
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P2272
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P2272.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P2272.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Introduction: Optical coherence tomography (OCT) is an imaging technique that can offer high resolution and real-time axial images of cellular microstructure at and below tissue surface. The objective of the study was to determine the usefulness of this technique in the bronchoscopic study of carcinoma in situ and severe dysplasia and its role in deciding endoscopic treatment with curative intent in early central bronchogenic carcinoma (Stage 0 or IA).Methods: In all patients with suspected early lung cancer was performed an usual study that included a chest CT scan, PET/CT and autofluorescence bronchoscopy (AFB). Upon inspection by AFB, an OCT was performed by inserting a probe into the working channel of the bronchoscope. Were recorded lesion characteristics, the wall thickness and length. After OCT, a biopsy with forceps or cryo probe was taken in the same procedure.Results: We studied 7 patients with 11 endobronchial preinvasive lesions. Initial indication for bronchoscopy was pneumonia (2), pulmonary nodule or mass (2), periodic review after lung cancer surgery (2) and hemoptysis (1). In nine lesions were detected structural changes and thickening of the mucosa between 0.28 to 0.73 mm for carcinoma in situ and 0.36 to 0.59 mm for moderate or severe dysplasia. Two carcinomas in situ were not detected by OCT; one of those previously treated with cryotherapy without visible lesions after previous biopsy.Conclusions: OCT combined with AFB is a useful technique to select candidates for endoscopic treatment with curative intent and evaluating degree of depth invasion into the mucosa. Suspecting preinvasive endobronchial lesion should be performed an OCT before biopsy or endoscopic treatment.