RT Journal Article SR Electronic T1 Usefulness of admission red cell distribution Width as a predictor of early mortality in patients with severe exacerbation of chronic obstructive pulmonary disease JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P2158 VO 42 IS Suppl 57 A1 Ekrem Seyhan A1 Sinem Sökücü A1 Imran Ömür YR 2013 UL http://erj.ersjournals.com/content/42/Suppl_57/P2158.abstract AB Background: Red cell distribution width (RDW) is strongly associated with prognosis in cardiopulmonary disorders such as coronary artery disease, acute pulmonary emboli, acute heart failure, and pulmonary hypertension. Chronic obstructive pulmonary disease (COPD) patients with attact is frequently associated with right ventricular loading and pulmonary hypertension. The aim of this study was to investigate the relation between admission RDW and early mortality in patients with severe exacerbation of COPD.Method: Two hundred five patients with confirmed in COPD patients with attact were included. Demographic, clinical, echocardiographic, and laboratory characteristics were registered and recorded COPD deaths were registered as outcomes.Results: RDW was positively correlated with C-reactive protein (CRP) (p< 0.05), right ventricular dysfunction (RVD) (P< 0.001), and pulmonary arterial hypertension (PAH) (P= 0.02). Increased RDW >15.5 % on admission, PaCO2, CRP levels, presence of RVD, and presence of PAH were found to have prognostic significance in univariate analysis. Only increased RDW >15.5 % on admission (p= 0.012) and the presence of RVD (p <0.001) remained associated with increased risk for acute COPD-related early mortality in a multivariate Cox proportional-hazards model.Conclusion: COPD patients with RDW levels during exacerbation are at increased risk of early mortality.